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Melanocortin PeptidesNeurovascular Research🔬 RUO

PT-141 (Bremelanotide)

Molecular Data

Formula

C50H68N14O10

Mol. Weight

1025.18 Da

CAS Number

189691-06-3

Purity

≥98% (HPLC)

Appearance

White lyophilized powder

Storage

-20°C, desiccated

Research Overview
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist derived from the naturally occurring alpha-MSH peptide. Unlike its predecessor Melanotan II, PT-141 was specifically designed for melanocortin-4 receptor (MC4R) selectivity. The compound's cyclic structure provides enhanced stability and receptor specificity. In research settings, PT-141 is a valuable tool for studying melanocortin receptor pharmacology, central nervous system signaling pathways, and neuroendocrine mechanisms. The peptide has been extensively characterized in receptor binding assays and cell signaling studies. Well Memed compound for MC4R research. 🐸
Mechanism of Action
Activates MC3R and MC4R in the central nervous system, modulating neurovascular pathways involved in arousal and peripheral vascular tone.
Research Applications
Central neurovascular regulation, melanocortin pathway signaling, HPA axis modulation, social behavior studies, functional brain imaging research.
Key Research Findings
MC4R binding affinity studies show Ki values in the low nanomolar range (Hadley & Dorr, 2006, Peptides). In vitro cAMP assays demonstrate selective MC4R activation over MC3R and MC5R (Pfaus et al., 2007, Neurosci Biobehav Rev). Research reveals CNS penetration via circumventricular organs (Molinoff et al., 2003, Ann N Y Acad Sci). Receptor internalization studies show distinct trafficking patterns vs alpha-MSH (Giuliani et al., 2012, Eur J Pharmacol). Comparative melanocortin receptor selectivity profiling (Haskell-Luevano et al., 2001, J Med Chem).
References & Citations
PMID: 16814397, PMID: 17719100, PMID: 14668487, PMID: 22465551, PMID: 11585444
MANDATORY DISCLAIMER: PT-141 (Bremelanotide) as referenced on this page is strictly for in-vitro laboratory research and forensic applications only. It is NOT for human consumption, veterinary use, diagnostic purposes, therapeutic applications, or any form of bodily introduction. Any reference to research outcomes pertains exclusively to controlled laboratory settings. Researchers must comply with all applicable local, state, and federal regulations.
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All compounds, peptides, and research materials referenced on peptidepepe.com are strictly for in-vitro laboratory research and forensic applications only.These products are NOT intended for human consumption, veterinary use, diagnostic purposes, therapeutic applications, or any form of bodily introduction.By proceeding, you confirm that you are a qualified researcher or represent a legitimate research institution, and you agree to use all information on this platform exclusively for lawful research purposes.