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PE-22-28

Molecular Data

Formula

C35H53N9O11

Mol. Weight

800.00 Da

CAS Number

N/A

Purity

≥95% (HPLC)

Appearance

White lyophilized powder

Storage

-20°C, desiccated

Research Overview
PE-22-28 is a synthetic peptide fragment derived from the spadin analog of sortilin, targeting TREK-1 potassium channels.
Mechanism of Action
Blocks TREK-1 (TWIK-related potassium channel-1), enhancing serotonergic and noradrenergic neurotransmission in the central nervous system.
Research Applications
TREK-1 channel pharmacology, antidepressant mechanism research, serotonergic pathway studies, neuroplasticity investigation, rapid-onset anxiolytic modeling.
Key Research Findings
TREK-1 blockade produces antidepressant-like effects within days rather than weeks in rodent models. Enhanced hippocampal neurogenesis.
MANDATORY DISCLAIMER: PE-22-28 as referenced on this page is strictly for in-vitro laboratory research and forensic applications only. It is NOT for human consumption, veterinary use, diagnostic purposes, therapeutic applications, or any form of bodily introduction. Any reference to research outcomes pertains exclusively to controlled laboratory settings. Researchers must comply with all applicable local, state, and federal regulations.
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MANDATORY DISCLAIMER: All compounds and peptides referenced on peptidepepe.com are strictly for in-vitro laboratory research and forensic applications only. They are NOT for human consumption, veterinary use, diagnostic purposes, therapeutic applications, or any form of bodily introduction. Any reference to "subjects" pertains exclusively to laboratory research settings. $PEPPY is a utility-free meme token for community engagement only.

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All compounds, peptides, and research materials referenced on peptidepepe.com are strictly for in-vitro laboratory research and forensic applications only.These products are NOT intended for human consumption, veterinary use, diagnostic purposes, therapeutic applications, or any form of bodily introduction.By proceeding, you confirm that you are a qualified researcher or represent a legitimate research institution, and you agree to use all information on this platform exclusively for lawful research purposes.